Unlike patients with IDDM, those with NIDDM have detectable levels of circulating insulin. The two main disorders associated with NIDDM are:
1) A decreased ability of insulin to act on peripheral tissues. Usually called insulin resistance. To learn more about insulin resistance click here: http://my.webmd.com/content/article/56/65905.htm
2) Dysfunction of pancreatic beta cells, represented by the inability to produce sufficient amount of insulin to overcome insulin resistance.
result of these two disorders is the relative deficiency of insulin. Data
has found the primary reason for this to be the insulin resistance. Insulin
resistance usually precedes the clinical signs by as many as 20 years.